DCTN2 Polyclonal Antibody-BS78285 Magnetic plate Missense mutations in the Dyskerin

Missense mutations in the Dyskerin gene interfere with normal nuclear localization of Dyskerin and cause Dyskeratosis congenita (DKC)

and the C-terminal half contains 4 GoLoco motifs

Background: Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis

The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways

with only about 2% of the residues changing per 100 million years

DCTN2 Polyclonal Antibody-BS78285 Magnetic plate Missense mutations in the DyskerinDCTN2 Polyclonal Antibody Product: 1mg ml in PBS with 0. 02% sodium azide, 50% glycerol, pH7. 2 Sizes: 50l, 100l Catalogue Numbers: BS78285 50, BS78285 100 Swiss Prot: Q13561 Host: Rabbit DCTN2 Polyclonal Antibody BS78285 Storage and Stability: Store at 4C short term. Aliquot and store at 20C long term. Avoid freeze thaw cycles. Reactivity: Human, Rat Applications: WB, IF ICC All Applications: WB,1: 500 1: 2000 IF ICC,1: 20 1: 50 Background: This gene