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Work Cited: Bahardoust, M., Aghakhani, Z., Mousavi, S., Donyadideh, G., Ziafati, H., Alipour, H., Haghmoradi, M., Olamaeian, F., Tayebi, A., & Tizmaghz, A

Results of preclinical and in vitro studies have shown that activation of the IRR requires concentrations of ARA 290 greater than or equal to ~1 nmol/L (~1.3 ng/mL) (14)

While most people can benefit from a B12 injection, certain groups of people may see more obvious benefits than others: People With Signs Of B12 Deficiency Any person with the signs or symptoms of a B12 deficiency should pay a visit to their doctor, but an injection may still provide them with benefits

Several hold FDA approval for specific indications

Aggregation happens when degraded peptide fragments stick together, forming larger clumps

Folate must be checked alongside B12, and folate deficiency should never be treated in isolation when B12 is low, because doing so can mask the anaemia while neurological damage progresses