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This has been proven in mice: Valproic acid induced histone hyperacetylation had brain function effects on the next generation of mice through changes in sperm DNA methylation

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The balance between acetyl-CoA and coenzyme A (or CoA) is determined by L-carnitine, which is instrumental in the conversion of acetyl-CoA to acetyl-L-carnitine, which can be then dissipated out of the mitochondria, thus avoiding the accumulation of acyl groups inside the mitochondria, which could be toxic

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