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Injecting the solution slowly over 10-30 seconds to minimize discomfort and tissue irritation

Li et al., Shape design of high drug payload nanoparticles for more effective cancer therapy

Moreover, the toxicity to the healthy tissues maybe avoided by using exogenous stimuli responsive nanomaterials

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Ischemia was sustained for 34 min, after which clamps were removed, and successful reperfusion was visually confirmed

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