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Georgiades, F., Hosgood, S

Oxidative stress results from an imbalance between the oxidative and antioxidant systems of cells and tissues, leading to the excessive production of oxidative free radicals and related reactive oxygen species (ROS) [11]

Discussion Our concept, which we verified in several previous paper [24, 32, 33, 42], is that if we mimic the specific expression pattern of nutrient transporters at the BBB with a combination of two or three different ligands a more specific targeting of nanoparticles across the BBB can be achieved

At higher concentrations, the relative loss is smaller, but it still occurs

10.1039/d3fo01659e 276 ZhengS.MaM.ChenY.LiM

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