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The Peptide Mechanisms That Target Venous Wall Integrity Venous insufficiency and varicose vein formation fundamentally involve three overlapping pathological processes: endothelial dysfunction (the inner lining of veins loses its barrier function and regulatory capacity), extracellular matrix degradation (collagen and elastin fibers that give vein walls structural strength break down faster than they're replaced), and chronic low-grade inflammation that compounds both problems

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Med Sci Monit Int Med J Exp Clin Res 25:4068 Li Y-C, He S-M, He Z-X et al (2014) Plumbagin induces apoptotic and autophagic cell death through inhibition of the PI3K/Akt/mTOR pathway in human non-small cell lung cancer cells