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European Journal of Endocrinology (1998) 7

They can also cause both short and long term side effects, and they dont get to the root of the problem

Unlike earlier broad-spectrum senolytics that can harm healthy tissue, FOXO4-DRI targets a molecular interaction unique to senescent cells

However, in the 1980s this hypothesis was changed by the identification of IGF-I production in numerous tissues (Figure 6)