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10.1172/JCI111583 103 KoF

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This was often accompanied by enrichment of pro-inflammatory Proteobacteria and depletion of protective phyla such as Verrucomicrobia, indicating a shift toward inflammation and barrier dysfunction (Stolfi et al., 2022)

Similarly, in macrophages, classical activation of pro-inflammatory M1 macrophages promotes glycolysis to support antimicrobial function and cytokine production, while anti-inflammatory M2 macrophages primarily utilize OXPHOS and FAO for tissue repair and homeostasis (52, 53)

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