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Studies that used 1 mg/day in oral and intravenous trials did not show meaningfully better outcomes than lower doses, and higher doses were associated with more reports of headache, diarrhea, and gastrointestinal effects

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Lesion anatomy was classified from neuroimaging, and PWS was defined as transient neurological symptoms compatible with posterior circulation occurring 2-7 days before stroke onset

Biochim Biophys Acta (2016) 1863:505

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some may trial high-dose oral with close monitoring (NHS)