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Clin Transl Med

PMID: 20190676

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The central nervous system can adapt to sequential monoamine antidepressant exposure via acquired or oppositional tolerance, which may contribute to resistance [31, 32]

4.4 Interactions between cartilage and synovium 4.4.1 Interplay between cytokines released by chondrocytes and synovial cells When cartilage is damaged, chondrocytes release proteoglycan fragments, type II collagen fragments, and diverse injury-associated factors that synovial cell surface pattern recognition receptors (PRRs) can detect, prompting synovial hyperplasia and proinflammatory cytokine secretion (139)

Because copper is both essential and potentially toxic in excess, the body maintains copper homeostasis within tight limits, and repeated systemic delivery of a copper-carrying molecule is, in effect, copper supplementation by an unusual route