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The D51 series distinguishes B12 deficiency by its underlying cause, which directly affects coding specificity and reimbursement

The investigation of the amino acid residues controlling the two activities (monophenolase and diphenolase) in PPOs and the quantification of their influence on the catalytic activity represent a tough challenge in this field and has remained unclear over the last decades

10.1158/1535-7163.MCT-07-0553 Mol

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Using Poor Quality Fillers: Many cheap supplements use binders and fillers that can actually cause gut irritation

As a result, a deficiency in B12 has been linked to symptoms of depression, anxiety, and irritability