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Overall, due to the lack of clinical trials, arginase inhibitors are not currently recommended for the prevention or treatment of cardiovascular disease in clinical practice guidelines
Following single-dose administration of 30.58 or 61.48 mg HTY, peak plasma concentration was achieved at 30 min, with primary circulating metabolites being homovanillic acid, HTY-3-O-sulfate, and 3,4-dihydroxyphenylacetic acid detected in both plasma and urine, supporting the systemic absorption and metabolite formation observed in animal models [38]
S2CID 73727755