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With pivotal data published in the New England Journal of Medicine, a missed head-to-head endpoint against Eli Lillys tirzepatide, and fresh diabetes results presented in June 2026, the CagriSema FDA review carries unusual complexity for a drug that has already reset expectations across the weight management field

Training intensity: the benefits and safety of using the reps in reserve method [53:00]

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For example, 6% of those 3 months) unexplained gastrointestinal symptoms (e.g., pain or diarrhea), reflecting impaired regeneration of epithelial cells

Burke RE, Fahn S, Marsden CD

One critical observation: the weight loss curves had not plateaued at week 46