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In the only study to date examining the role of pre-extinction stress on appetitive memories in a clinical population, administration of cortisol before exposure to alcohol cues decreased within-session cravings in those with a severe alcohol use disorder but increased cravings in those with less severe symptoms [63]

The fleeting sense of euphoria caused by substances often leads to significant psychological distress and possibly brain damage

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LCF refers to cigarette filters that littered by smokers then collected from the urban environment or public areas by urban cleaning systems

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