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Critically, nicotine (10 mM, up to 14 days) also reduced the formation of bone-like nodules, structures formed by the mineralisation of the extracellular matrix secreted by osteoblasts [48]

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Adult C57BL6 male mice were fed a normal chow diet or HFD and received twice daily injections of nicotine (0.75 mg/kg BW, IP) or saline for 10 weeks