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It is worth noting that there are 86 drugs in clinical phase IV, suggesting that the strategy of using old drugs for new use, such as repositioning marketed metabolites and antioxidants, can effectively shorten the research and development cycle

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Methodology: Adhering to the PRISMA guidelines, we conducted a comprehensive search in PubMed/Medline, Web of Science, Scopus, and Google Scholar databases without date restrictions, including articles in both Spanish and English

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