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Increasing evidence suggests that nicotine and its derivatives, such as N-nitrosonornicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanonee can directly activate nAChRs to promote cell growth and angiogenesis and inhibit the drug-induced apoptosis of cancer cells (75)

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Being under nicotines influence, you may even over socialise with others, or you may isolate yourself