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[ IIa ] Saag KG, Cerhan JR, Kolluri S, Ohashi K, Hunninghake GW, Schwartz DA

12 April 1939 via Google news

60 When consumed through smoking or vaping, nicotine: Increases heart rate and blood pressure, Causes blood vessels to constrict, with a resultant temperature drop in hands and feet, Alters brain waves, and Relaxes muscles

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In contrast, 80% of the rats exposed to e-cigarette vapor using NC heating units developed clinical acute respiratory distress when a 70W power setting was employed