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Simultaneously, a valve opens, from which the butane is released, which is vaporized (depressurized) as soon as it exits the container

At that time, it was a popular cigarette in US

In answer to the more direct question of how much nicotine per day is safe, a reasonable starting point might be, "How much nicotine might it take to poison someone?" The ECHA currently gives an "acute toxicity estimate" (ATE) for nicotine via the oral route to be 5 mg/kg bw [7] , meaning 5mg of nicotine for every kilogram of bodyweight of the person consuming the nicotine

The FDA reviewed all available science and confirmed that IQOS is distinctly different from cigarettes, because it has been demonstrated to reduce exposure to harmful chemicals

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