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After adjusting for these variables, e-cigarette users were 34 percent more likely to have a heart attack, 25 percent more likely to have coronary artery disease and 55 percent more likely to suffer from depression or anxiety

The 2015 editorial also raised concerns about conflicts of interest, noting that some researchers involved in developing the guesstimate had connections to Big Tobacco

Why it earned the top spot is worth the full breakdown below

Integration with smart home devices for automated responses

Encourage healthy activities: Engage in activities that distract from cravings and promote a smoke-free lifestyle