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Given that studies have failed to find an association between CYP2D6 polymorphism and incidence of depression (178), the most likely conclusion is the latter, in which individuals have an increased need to try different therapeutics in search of a positive therapeutic response (176, 177)

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These changes are often accompanied by other smoking-related findings, such as emphysema, DIP, and RB

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For a really thorough explanation of how MERV ratings are calculated, see this summary from the National Air Filtration Association